RILP (gene)

Rab interacting lysosomal protein

PDB rendering based on 1yhn.

Available structures
PDB	1yhn

Identifiers

RILP; FLJ31193; PP10141

External IDs

OMIM: 607848 MGI: 2144271 HomoloGene: 19596 GeneCards: RILP Gene

Gene Ontology
Molecular function	• Rab GTPase binding • Rab GTPase binding
Cellular component	• mitochondrion • lysosome • lysosomal membrane • late endosome • late endosome • endomembrane system • membrane • phagocytic vesicle membrane • cytoplasmic vesicle • late endosome membrane
Biological process	• endosome to lysosome transport • protein transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000167705

ENSMUSG00000038195

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
1.55 – 1.55 Mb

Chr 11:
75.32 – 75.33 Mb

PubMed search

Rab-interacting lysosomal protein is a protein that in humans is encoded by the RILP gene.^[1]^[2]

RILP, along with the GTPase RAB7 (MIM 602298), controls late endocytic transport.[supplied by OMIM]^[2]

Interactions

RILP (gene) has been shown to interact with RAB7A.^[1]^[3]

References

^ ^a ^b Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C (Feb 2001). "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes". EMBO J 20 (4): 683–93. doi:10.1093/emboj/20.4.683. PMC 145419. PMID 11179213. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=145419.
^ ^a ^b "Entrez Gene: RILP Rab interacting lysosomal protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83547.
^ Caplan, S; Hartnell L M, Aguilar R C, Naslavsky N, Bonifacino J S (Jul. 2001). "Human Vam6p promotes lysosome clustering and fusion in vivo". J. Cell Biol. (United States) 154 (1): 109–22. doi:10.1083/jcb.200102142. ISSN 0021-9525. PMC 2196876. PMID 11448994. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196876.

Further reading

Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
Jordens I, Fernandez-Borja M, Marsman M, et al. (2002). "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors". Curr. Biol. 11 (21): 1680–5. doi:10.1016/S0960-9822(01)00531-0. PMID 11696325.
Wang T, Hong W (2003). "Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein". Mol. Biol. Cell 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=138636.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180354.
Harrison RE, Bucci C, Vieira OV, et al. (2003). "Phagosomes Fuse with Late Endosomes and/or Lysosomes by Extension of Membrane Protrusions along Microtubules: Role of Rab7 and RILP". Mol. Cell. Biol. 23 (18): 6494–506. doi:10.1128/MCB.23.18.6494-6506.2003. PMC 193691. PMID 12944476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193691.
Wang T, Wong KK, Hong W (2004). "A Unique Region of RILP Distinguishes It from Its Related Proteins in Its Regulation of Lysosomal Morphology and Interaction with Rab7 and Rab34". Mol. Biol. Cell 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=329395.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Wu M, Wang T, Loh E, et al. (2005). "Structural basis for recruitment of RILP by small GTPase Rab7". EMBO J. 24 (8): 1491–501. doi:10.1038/sj.emboj.7600643. PMC 1142575. PMID 15933719. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142575.
Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
Shimojo M, Hersh LB (2006). "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF". J. Neurochem. 96 (4): 1130–8. doi:10.1111/j.1471-4159.2005.03608.x. PMID 16417580.
Marsman M, Jordens I, Rocha N, et al. (2006). "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment". Biochem. Biophys. Res. Commun. 344 (3): 747–56. doi:10.1016/j.bbrc.2006.03.178. PMID 16631113.
Progida C, Spinosa MR, De Luca A, Bucci C (2006). "RILP interacts with the VPS22 component of the ESCRT-II complex". Biochem. Biophys. Res. Commun. 347 (4): 1074–9. doi:10.1016/j.bbrc.2006.07.007. PMID 16857164.

PDB gallery

1yhn: Structure basis of RILP recruitment by Rab7